We have previously identified CarD as an essential trans... Sequence alignment (.fas format) of 831 CarD sequences. The Rockefeller University, New York, NY 10065. Overview; Fingerprint; Network; Relevant Research (2) Similar Profiles (12) If you made any changes in Pure these will be visible here soon. Sorry, you need to be a researcher to join ResearchGate. 年別の研究成果 . Deputy Editor, Cambridge Stella M. Hurtley (UK) Deputy Editor, Insights Julia Fahrenkamp-Uppenbrink (UK) Deputy Editors, Research Phillip D. Szuromi, Sacha Vignieri Senior Editorial Fellow Andrew M. Sugden (UK) Senior Editors Gemma Alderton (UK), Caroline Ash (UK), Brent Grocholski, Pamela J. Hines, Paula A. Kiberstis, Marc S. Lavine (Canada), Steve Mao, Ia… doi:10.1016/j.molcel.2014.03.040, Wu, J., & Chen, Z. J. Congratulations to James Chen, from the Darst lab, and Sofia Landi, from the Freiwald lab, on being named Schmidt Science Fellows! The University of Texas Southwestern Medical Center Rockefeller’s approach has inspired a generation of dedicated philanthropists across the West, from Bill Gates to Mark Zuckerberg, who recognize the value of innovative, entrepreneurial giving. Annual Review of Immunology, 32, 461–88. The search for new antibiotics against proven targets is one approach to combat multidrug-resistant tuberculosis (TB), a global threat. ... can chinese philanthropists learn from the rockefeller legacy? Xiao-Dong Li. http://dx.doi.org/10.7554/eLife.08505.025. See the complete profile on LinkedIn and discover James’ connections and jobs at similar companies. ... inside an infected cell,” says James Chen, a postdoctoral associate in Seth Darst’s lab and one of the study’s first authors. Constellation Pharmaceuticals . Congratulations to James Chen, from the Darst lab, and Sofia Landi, from the Freiwald lab, on being named Schmidt Science Fellows! Shanghai Institutes for Biological Sciences Chinese Academy of Sciences . 16. view article. Eliza Llewellyn. Mechanistic studies... We present an approach for preparing cryo-electron microscopy (cryo-EM) grids to study short-lived molecular states. Both the holo-RdRp and nsp13 are essential for viral replication and are targets f... SARS-CoV-2 is the causative agent of the 2019-2020 pandemic. Laguna Hills, CA … Qianwen Huang. Director, Center for Inflammation, doi:10.1016/j.cell.2010.03.029, Cai, X., Chiu, Y.-H., & Chen, Z. J. 17. view article. The site facilitates research and collaboration in academic endeavors. Atsuhiro Kanayama . Rifampicin (Rif) is an antibiotic that targets bacterial RNA polymerase (RNAP). Here, we characterized the effects of the antibiotic sorangicin A (Sor) on a Rif-resistant (RifR) RNAP found in clinically isolated RifR strains. Nigerian Barge Deal: A 1999 agreement between Enron and Merrill Lynch in which Enron transferred an interest in energy-producing barges located off the coast of Nigeria to Merrill Lynch. The emergence of Rif-resistant (Rif R ) Mtb presents a need for new antibiotics. James has 5 jobs listed on their profile. Courtney Chiu. Dr. James Chen's office location. Xiao-Dong Li. 13 . 17. view article. (2013). The essential bacterial transcription factor NusA stimulates both pausing and termination of transcription, thus playing a central role. James Chen, Graduate Fellow Jason Pinger, Alumnus/Alumna Meg Younger, Postdoctoral Fellow Tom Wiley (He/Him), Genome Maintenance Staff Devon Collins, Postdoctoral Fellow Seon-Hui Hong, Postdoctoral Fellow Edmondo Campisi, Research Associate Anonymous, Graduate Fellow Andrew Wong, Graduate Fellow Laura Menocal, Graduate Fellow How TraR and its homologs regulate transcription is unclear. Importance: To identify the structural determinants of Fdx binding to RNAP, we determined the 3.4 Å cryo-electron... Fidaxomicin (Fdx) is an antimicrobial RNA polymerase (RNAP) inhibitor highly effective against Mycobacterium tuberculosis RNAP in vitro , but clinical use of Fdx is limited to treating Clostridium difficile intestinal infections due to poor absorption. 3 Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, NY 10065, USA. Novartis Pharmaceuticals . 08. NPI number. 27 . 03 . (2013). Here, we report single-particle electr... Fidaxomicin (Fdx) is an antimicrobial RNA polymerase (RNAP) inhibitor highly effective againstMycobacterium tuberculosisRNAP in vitro, but clinical use of Fdx is limited to treatingClostridium difficileintestinal infections due to poor absorption. Prior to that he was a Consultant at the Monitor Group in Shanghai. DOI: for YR catalysis and the relationship between the YRs and the TopIBs, we have analyzed the in vivo... Join ResearchGate to find the people and research you need to help your work. DOI: All rights reserved. Backtracking, the reverse motion of the transcriptase enzyme on the nucleic acid template, is a universal regulatory feature of transcription in cellular organisms but its role in viruses is not established. Transcription of DNA is a fundamental process in all cellular organisms. Stock, Forex, Commodities, Options, Futures & Cryptocurrency Market. Mfd mediates TCR in bacteria by removing the stalled RNAP concealing the lesion and recruiting Uvr(A)BC. Rockefeller University - Laboratory of Molecular Biophysics. Effects of TraR mimic the combined effects of DksA and its cofactor ppGpp, but the structural basis for regulation by these factors remains unclear. 10 . Biographie. Rockefeller faculty are singularly committed to making transformative discoveries in the biomedical sciences. He joined the Stanford faculty in 2003, and his research interests span organic chemistry, chemical biology, developmental biology, and cancer biology. (2014). One of these factors is the nsp13 helicase. Rockefeller University; 2020 2021. The SARS-CoV-2 genome is replicated and transcribed by the RNA-dependent RNA polymerase holoenzyme (subunits nsp7/nsp82/nsp12) along with a cast of accessory factors. Fajian Hou. James P. Allison (M. D. Anderson ... Zhijian James Chen, UT Southwestern Medical Center and Howard Hughes Medical Institute, Dallas, for elucidating how DNA triggers immune and autoimmune responses from the interior of a cell through the discovery of the DNA-sensing enzyme cGAS. James Chenが活動している研究トピックを掘り下げます。このトピックラベルは、この … Log in | Register; Checkout If you need immediate assistance, call 877-SSRNHelp (877 777 6435) in the United States, or +1 212 448 2500 outside of the United States, 8:30AM to 6:00PM U.S. Eastern, Monday - Friday. Cell, 141(2), 315–330. JAMES CHEN Agent Address 37 ANTIQUE ROSE IRVINE CA 92620 Directors / Officers. 2020. Site Map | The Rockefeller University, New York, NY 10065, USA. Mei Hong . 03 . 16. view article. Both the holo-RdRp and nsp13 are essential for viral replication and are targe... We present an approach for preparing cryoEM grids to study short-lived molecular states. James Chen. View James Chen’s profile on LinkedIn, the world’s largest professional community. Atsuhiro Kanayama . Diverse mechanisms are used among and within the different branches to regulate transcription initiation. Rockefeller University . James Chen. Research activity per year. 12. The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling. 10 . Copyright © 2004–2012 Hon-Ren Huang. Mei Hong . James Zhao is a Founding Partner at LYFE Capital. 10 . raconteur. As is tradition, each student was presented by his or her mentor, and the students were formally awarded their degrees by […] Join ResearchGate to contact this researcher and connect with your scientific community. doi:10.1126/science.1244040, Sun, L., Wu, J., Du, F., Chen, X., & Chen, Z. J. Rockefeller University; 2020 2021. james chen’s moonshot. why james chen is a man on mission to restore eyesight for all by 2035. Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex, Structural basis for transcription complex disruption by the Mfd translocase, The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase, Native Mass Spectrometry-Based Screening for Optimal Sample Preparation in Single-Particle Cryo-EM, Diverse and unified mechanisms of transcription initiation in bacteria, Structural basis for helicase-polymerase coupling in the SARS-CoV-2 replication-transcription complex, Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex, Stepwise Promoter Melting by Bacterial RNA Polymerase, Native Mass Spectrometry-Based Screening for Optimal Sample Preparation in Single Particle Cryo-EM, E. coli TraR allosterically regulates transcription initiation by altering RNA polymerase conformation, E. coli TraR allosterically regulates transcription initiation by altering RNA polymerase conformation and dynamics, Eliminating effects of particle adsorption to the air/water interface in single-particle cryo-electron microscopy: Bacterial RNA polymerase and CHAPSO, Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding, Structural Basis for NusA Stabilized Transcriptional Pausing, Document S2. Friday Lecture Series doi:10.1146/annurev-immunol-032713-120156, The Rockefeller University | 1230 York Avenue, New York, NY 10065 | 212-327-8000 James K. Chen is part of Stanford Profiles, official site for faculty, postdocs, students and staff information (Expertise, Bio, Research, Publications, and more). DOI: Welcome to ChemBioLinks, a carefully curated directory of investigators working along the interface of chemistry and biology. 3:45 p.m., Caspary Auditorium, Zhijian “James” Chen, Ph.D. Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Transcription initiation requires formation of the open promoter complex (RPo). (2014). James Chen received his A.B. Here, we use cryo-electron microscopy t... TraR and its homolog DksA are bacterial proteins that regulate transcription initiation by binding directly to RNA polymerase (RNAP) rather than to promoter DNA. Download the 2018-2020 Scientific Prospectus April 28, 2021. 11 . Orientation bias limits the angular information used to generate three-dimensional maps and thus affects the reliability and interpretability of the structural models. These topic labels come from the works of this person. To better understand the requirements James Chen The CBT Symposium, held on September 25, brought together leading chemical biologists who are pioneering new synthetic approaches to investigate challenging questions in biology and molecular medicine.. Only verified researchers can join ResearchGate and send messages to other members. To generate RPo, RNA polymerase (RNAP) unwinds the DNA duplex to form the transcription bubble and loads the DNA into the RNAP active site. Here we present evidence that backtracking extends into the viral realm, where backtracking by the SARS-CoV-2 RNA-dependent RNA polymerase (Rd... Transcription-coupled repair (TCR) is a sub-pathway of nucleotide excision repair (NER) that preferentially removes lesions from the template-strand (t-strand) that stall RNA polymerase (RNAP) elongation complexes (EC). Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), remains a major global health problem. doi:10.1126/science.1240933, Li, X.-D., Wu, J., Gao, D., Wang, H., Sun, L., & Chen, Z. J. Scientists release error-free genomes of 16 animals—with another 70,000 coming up The flightless kakapo of New Zealand is in trouble. The SARS-CoV-2 genome is replicated-transcribed by the RNA-dependent RNA polymerase holoenzyme (subunits nsp7/nsp82/nsp12) along with a cast of accessory factors. Figures S1–S7 and Tables S1 and S2, Fidaxomicin jams mycobacterium tuberculosis RNA polymerase motions needed for initiation via RBPA contacts, Fidaxomicin jams M. tuberculosis RNA polymerase motions needed for initiation via RbpA contacts, Structural biology of bacterial transcription, 6S RNA Mimics B-Form DNA to Regulate Escherichia coli RNA Polymerase, Effects of Increasing the Affinity of CarD for RNA Polymerase on Mycobacterium tuberculosis Growth, rRNA Transcription, and Virulence, Mycobacterial RNA polymerase forms unstable open promoter complexes that are stabilized by CarD, Requirements for catalysis in the Cre recombinase active site. can chinese philanthropists learn from the rockefeller legacy? Research Professor, Department of Molecular Biology, Rockefeller University - Laboratory of Mass Spectrometry and Gaseous Ion Chemistry. 2 Department Microbial Natural Products, Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Centre for Infection Research, Saarland University, 66123 Saarbrücken, Germany. Effects of TraR mimic the combined effects of DksA and its cofactor ppGpp. Xiamen University . wired. James Chen. view article . http://dx.doi.org/10.7554/eLife.25478.024. 29 . http://dx.doi.org/10.7554/eLife.25478.023, Results of superpositions of TEC models. Rockefeller University; 2020 2021. Science, 341(6152), 1390–1394. George L. MacGregor Distinguished Chair in Biomedical Sciences, Bacterial 6S RNAs globally regulate transcription by binding RNA polymerase (RNAP) holoenzyme and competing with promoter DNA. Investigator, Howard Hughes Medical Institute, Enemy Within – Immune and Autoimmune Responses to cytosolic DNA and RNA, Gao, D., Wu, J., Wu, Y.-T., Du, F., Aroh, C., Yan, N., … Chen, Z. J. We used cryo-electron mic... Rifampicin (Rif) is a first-line therapeutic used to treat the infectious disease tuberculosis (TB), which is caused by the pathogen Mycobacterium tuberculosis ( Mtb ). Dive into the research topics where James Chen is active. Copyright Complaints, Updated Structural Genomics Knowledgebase Re-launched, Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses, Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects, Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway, Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity, The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling, Innate immune sensing and signaling of cytosolic nucleic acids. Read more to learn about Dr. James Chen, MD's background, education, and other specialties. 24331 El Toro Rd, 200. Male. Courtney Chiu's 5 research works with 38 citations and 321 reads, including: Native Mass Spectrometry-Based Screening for Optimal Sample Preparation in Single-Particle Cryo-EM The importance of giving back was instilled in him by his father, Robert Yet-Sen Chen, whose lifetime of philanthropic work led to the creation of The Chen Yet-Sen Family Foundation, which focuses on improving early childhood literacy. doi:10.1126/science.1232458, Zeng, W., Sun, L., Jiang, X., Chen, X., Hou, F., Adhikari, A., … Chen, Z. J. Rockefeller University . Rockefeller, the grandson of Standard Oil founder and America's first billionaire John D. Rockefeller, died on March 20, 2017. James Darnell est le fils d'une mère diététicienne [1]. 16. view article. One of these factors is the nsp13 helicase. To generate the open complex, the conserved catalytic core of the RNAP combines with initiation factors to locate promoter DNA, unwind 12–14 base pairs of the DNA duplex and load the template-strand DNA into the RNAP active site.... Transcriptional pausing by RNA polymerases (RNAPs) is a key mechanism to regulate gene expression in all kingdoms of life and is a prerequisite for transcription termination.
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